
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a peptide consisting of 16 amino acids
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a peptide consisting of 16 amino acids. Unlike many peptides that are encoded by the nuclear genome, MOTS-c is unique in that it is encoded within the mitochondrial genome. In laboratory research settings, it has garnered significant attention as a mitochondrial-derived peptide (MDP) that appears to act as a signaling molecule regulating metabolic homeostasis. Scientific literature extensively explores MOTS-c for its potential role as an “exercise mimetic,” investigating its influence on physiological processes such as fatty acid oxidation, glucose metabolism, and insulin sensitivity. It is frequently utilized in studies examining the AMP-activated protein kinase (AMPK) pathway and its downstream effects on cellular energy balance and weight regulation in non-human models.
For research and educational purposes. Not intended for human consumption. Statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease.

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